Discover a masterpiece named Florence

“The greatest concentration of universally renowned works of art in the world is found [in Florence]”, noted the United Nations World Heritage commission in 1982, when it inducted the city’s historic center. They might have added that the greatest tourist logjams in the world are also, arguably, in Florence; if Goliath had encountered Michaelangelo’s "David" in 2007, he would have had to wade through a crowd as densely packed as that in a Tokyo subway car to get to him. So while there are few travel destinations as rich in history and eye-popping beauty, Florence can no longer be fully appreciated year round. Instead, take the following daylong itinerary between late October and early April, when this Renaissance epicenter weaves her charms peacefully.

8:15 a.m.-9:15 a.m.: Swing by David’s house, better known as the Galleria Dell’Academia, to marvel at the sexy rock star of Renaissance sculpture. "David" was created by Michelangelo in 1504 to celebrate the ouster of the Medici clan from power in Florence. Whoops—they were back in control a few years after the statue was erected, but the "David" was so spectacular that the Medicis let it stand. Book your Academia tickets in advance to sidestep the lines and make time for Michaelangelo’s unfinished but mesmerizing statues of four slaves in a nearby gallery.

9:30 a.m.-noon:  Head from the marvels of Michelangelo to a work that master marveled at: Lorenzo Ghiberti’s Baptistry Doors. In elegant detail, these bronze doors depict scenes from the "Old Testament"; Michelangelo was so taken by them, he dubbed them “The Gates of Paradise” and they’ve been known by that moniker ever since. From the Baptistry, walk across the Duomo, which was created by Ghiberti’s rival, Brunelleschi (who also vied for the door commission). A marvel of engineering, it’s based on Brunelleschi’s study of the Pantheon in Rome (for the complete story, read Ross King’s superb book “Brunelleschi’s Dome”).

Morning alternative: Wile away the morning with the Medicis, the Midas-rich ruling family who bankrolled most of Florence's greatest works of art and architecture. That old saw, "You can't take it with you", apparently had no meaning to this clan, as you'll see when you visit their over-the-top opulent tombs, with sculptures by Michelangelo and walls inlaid with the costliest of marbles and precious stones. From here, make your way to the Boboli Gardens, right behind the Pitti Palace, which the Medicis filled with more statuary from Michelangelo (copies are here now to protect the originals), a massive Egyptian obelisk, classic grottoes and garden temples, and carefully groomed plants and trees.

Noon-12:40 p.m.: No time for a long sit down lunch; instead, head to the wine bar of one of Tuscany’s most famous wineries, Cantinetta del Verrazzano. Wash down a crusty sandwich with one of their signature chiantis.

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1 p.m.-2:30 p.m.: You’ve seen his work several times already, now it’s time to pay your respects to Michelangelo with a visit to his last resting place, the church of Santa Croce (Galileo, Ghiberti, Machiavelli and opera composer Rossini are also entombed here). A soaring Gothic beauty with Brunelleschi’s other masterwork attached (the exquisite Pazzi Chapel), it’s literally overrun with great works of art including important frescoes by Giotto and a surprisingly modern crucifix by Donatello. After you leave, nip over to the nearby Il Gelato Vivoli for the finest gelato in Florence (and that’s saying a lot).

3 p.m.- 7 p.m.: Pony up the extra $3 to book in advance and skip the line at the Gallerie della Uffizi. In a museum this rich—every Renaissance master is represented here and often by his greatest masterpiece—time ticks away far too fast. Along with important Italian works by Botticelli, Giotto, da Vinci, Ucello and others, are an assortment of gems from Durer, Memling, Rembrandt and Holbein—colleagues to the north.

Afternoon alternative: Ditch the art marathon for an afternoon shopping spree (or window shopping session—curse you, mighty euro). Leather has been the city’s prime “get” for decades, and though mass produced goods now dominate the open markets, it’s possible to purchase butter-soft, finely crafted goods and watch the artisans at work at the Scuola del Cuoio (Leather School) of Santa Croce. There are other great leather stores in Florence, but this is the most fun to visit.

7:30 p.m.-10 p.m.: Mangia! Settle in for a leisurely Tuscan feast at Il Latini, where you’ll dine at a convivial common table under a curtain of hanging ham hocks. Skip the menu and instead go for the set meal, which includes unlimited wine and delicious trattoria fare (pastas, roast meats, biscotti with vin santo).

Pauline Frommer is the creator of the new Pauline Frommer guides in bookstores now. Her book, Pauline Frommer's New York, was named Best Guidebook of the Year by the North American Travel Journalists Association.

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